Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?
Author:
Affiliation:
1. Departments of Chemistry and Molecular Medicine, and ‡The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
Skaggs Institute for Chemical Biology
Lita Annenberg Hazen Foundation
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.7b00579
Reference63 articles.
1. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines
2. Amyloid Formation in Light Chain Amyloidosis
3. Immunoglobulin light chain amyloidosis
4. Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis
5. Evidence That Amyloidogenic Light Chains Undergo Antigen-Driven Selection
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