Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy-Reference-Cited by-同舟云学术

Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy

Published:2018-08-27 Issue:38 Volume:57 Page:5576-5590
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Manley Paul W.¹,Caravatti Giorgio¹,Furet Pascal¹,Roesel Johannes²,Tran Phi³,Wagner Trixie¹,Wartmann Markus²

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis International AG, CH-4002 Basel, Switzerland

2. Oncology Disease Area, Novartis Institutes for Biomedical Research, Novartis International AG, CH-4002 Basel, Switzerland

3. Department of Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00727

Reference112 articles.

1. The Protein Kinase Complement of the Human Genome

2. Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with aFLT3Mutation

3. Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis

4. Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The multi-kinase inhibitor CG-806 exerts anti-cancer activity against acute myeloid leukemia by co-targeting FLT3, BTK, and aurora kinases;Leukemia & Lymphoma;2024-06-13

2. Landscape of FLT3 Variations Associated with Structural and Functional Impact on Acute Myeloid Leukemia: A Computational Study;International Journal of Molecular Sciences;2024-03-18

3. Theoretical models of staurosporine and analogs uncover detailed structural information in biological solution;Journal of Molecular Graphics and Modelling;2024-01

4. Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer;Nature Communications;2023-10-10

5. Research Advances in Mast Cell Biology and Their Translation Into Novel Therapies for Anaphylaxis;The Journal of Allergy and Clinical Immunology: In Practice;2023-07