Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR-Reference-Cited by-同舟云学术

Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR

Published:2018-12-06 Issue:6 Volume:58 Page:526-533
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Bouvier Guillaume¹^ORCID,Simenel Catherine²,Jang Jichan³⁴,Kalia Nitin P.⁵,Choi Inhee³,Nilges Michael¹^ORCID,Pethe Kevin³⁵,Izadi-Pruneyre Nadia²^ORCID

Affiliation:

1. Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3528, C3BI, USR3756 Paris, France

2. NMR of Biomolecules Unit, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS, UMR3528 Paris, France

3. Institut Pasteur Korea, 13488 Gyeonggi-do, Korea

4. Division of Life Science, Research Institute of Life Science, Gyeongsang National University, Jinju, Korea 52828

5. Lee Kong Chian School of Medicine and School of Biological Sciences, Nanyang Technological University, 636921 Singapore

Funder

National Medical Research Council

National Research Foundation of Korea

Fondation pour la Recherche M?dicale

Centre National de la Recherche Scientifique

Institut Pasteur

FP7 Ideas: European Research Council

Gyeonggi-do Province of Korea

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00975

Reference30 articles.

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2. Tuberculosis drug discovery in the post‐post‐genomic era

3. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

4. ClinicalTrials.gov. (2018) A dose-escalation study to evaluate safety, tolerability and pharmacokinetics of single doses of Q203 in normal healthy, male and female volunteers. https://clinicaltrials.gov/ct2/show/.

5. Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi

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