Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α-Amylase
Author:
Affiliation:
1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada
2. Michael Smith Laboratories, 2125 East Mall, Vancouver, British Columbia V6T 1Z4, Canada
Funder
Institute of Genetics
GlycoNet Canada
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00825
Reference15 articles.
1. The structure of human pancreaticα-amylase at 1.8 Å resolution and comparisons with related enzymes
2. In Situ Extension as an Approach for Identifying Novel α-Amylase Inhibitors
3. Proteinaceous α-amylase inhibitors
4. Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide
5. Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors
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