Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule-Reference-Cited by-同舟云学术

Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule

Published:2018-08-13 Issue:39 Volume:57 Page:5748-5758
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Bokoch Michael P.¹²^ORCID,Jo Hyunil³,Valcourt James R.⁴,Srinivasan Yoga¹,Pan Albert C.⁴,Capponi Sara¹,Grabe Michael¹,Dror Ron O.⁴,Shaw David E.⁴⁵^ORCID,DeGrado William F.³^ORCID,Coughlin Shaun R.¹

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, California 94158, United States

2. Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, United States

3. Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States

4. D. E. Shaw Research, New York, New York 10036, United States

5. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States

Funder

National Heart, Lung, and Blood Institute

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00577

Reference37 articles.

1. The selectivity of β -adrenoceptor antagonists at the human β 1, β 2 and β 3 adrenoceptors

2. GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

3. Structure-Function of the G Protein–Coupled Receptor Superfamily

4. Structure and dynamics of the M3 muscarinic acetylcholine receptor

5. Pathway and mechanism of drug binding to G-protein-coupled receptors

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