Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation-Reference-Cited by-同舟云学术

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation

Published:2018-04-02 Issue:16 Volume:57 Page:2373-2382
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Macháčková Kateřina¹,Chrudinová Martina¹,Radosavljević Jelena¹,Potalitsyn Pavlo¹,Křížková Květoslava¹,Fábry Milan²,Selicharová Irena¹,Collinsová Michaela¹,Brzozowski Andrzej M.³^ORCID,Žáková Lenka¹,Jiráček Jiří¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám 2, 166 10 Prague 6, Czech Republic

2. Institute of Molecular Genetics, The Czech Academy of Sciences, Flemingovo n. 2, 166 37 Prague 6, Czech Republic

3. York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York YO10 5DD, United Kingdom

Funder

Research Councils UK

Grantov?? Agentura ??esk?? Republiky

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.biochem.7b01260

Reference62 articles.

1. Chapter 2 Structure and evolution of insulin and insulin-like growth factors in chordates

2. Insulin Through the Ages: Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone

3. Ancient Divergence of Insulin and Insulin-Like Growth Factor

4. Phylogeny of the insulin-like growth factors (IGFS) and receptors: A molecular approach

5. Molecular interactions of the IGF system

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