Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics-Reference-Cited by-同舟云学术

Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics

Published:2015-12-31 Issue:2 Volume:55 Page:348-359
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Konkle Mary E.¹,Blobaum Anna L.¹,Moth Christopher W.¹,Prusakiewicz Jeffery J.¹,Xu Shu¹,Ghebreselasie Kebreab¹,Akingbade Dapo¹,Jacobs Aaron T.¹,Rouzer Carol A.¹,Lybrand Terry P.¹,Marnett Lawrence J.¹

Affiliation:

1. Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232-0146, United States

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.biochem.5b01222

Reference46 articles.

1. Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

2. Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition