Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase-Reference-Cited by-同舟云学术

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase

Published:2016-03-29 Issue:14 Volume:55 Page:2153-2162
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Isaksen Geir Villy¹,Hopmann Kathrin Helen¹,Åqvist Johan²,Brandsdal Bjørn Olav¹

Affiliation:

1. Centre for Theoretical and Computational Chemistry, Department of Chemistry, Faculty of Science and Technology, University of Tromsø, N9037 Tromsø, Norway

2. Department of Cell & Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden

Funder

Norges Forskningsråd

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.5b01347

Reference65 articles.

1. Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates

2. Purine Nucleoside Phosphorylase Deficiency Associated with Selective Cellular Immunodeficiency

3. NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITY

4. DESOXYRIBOSE-1-PHOSPHATE

5. Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.

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