Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1
Author:
Affiliation:
1. Department of Chemistry, University of California, Davis, California 95616, United States
2. Department of Molecular and Cellular Biology, University of California, Davis, California 95616, United States
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.3c00405
Reference34 articles.
1. A-to-I RNA editing — immune protector and transcriptome diversifier
2. RNA Editing by Adenosine Deaminases That Act on RNA
3. Adenosine Deaminases That Act on RNA (ADARs)
4. Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy
5. ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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