Structure–Function Studies of the Antibiotic Target l,l-Diaminopimelate Aminotransferase from Verrucomicrobium spinosum Reveal an Unusual Oligomeric Structure-Reference-Cited by-同舟云学术

Structure–Function Studies of the Antibiotic Target l,l-Diaminopimelate Aminotransferase from Verrucomicrobium spinosum Reveal an Unusual Oligomeric Structure

Published:2020-06-01 Issue:24 Volume:59 Page:2274-2288
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Weatherhead Anthony W.¹,Crowther Jennifer M.¹,Horne Christopher R.¹,Meng Yanxiang¹,Coombes David¹,Currie Michael J.¹,Watkin Serena A. J.¹,Adams Lily E.²,Parthasarathy Anutthaman²,Dobson Renwick C. J.¹³,Hudson André O.²^ORCID

Affiliation:

1. Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, P.O. Box 4800, Christchurch 8140, New Zealand

2. Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York 14623-5603, United States

3. Bio21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia

Funder

Ministry of Business, Innovation and Employment

Army Research Office

Royal Marsden NHS Foundation Trust

National Institute of General Medical Sciences

Biomolecular Interaction Centre, University of Canterbury

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00185

Reference69 articles.

1. An ll-Diaminopimelate Aminotransferase Defines a Novel Variant of the Lysine Biosynthesis Pathway in Plants

2. Enzymology of Bacterial Lysine Biosynthesis

3. Methanococci Use the Diaminopimelate Aminotransferase (DapL) Pathway for Lysine Biosynthesis

4. L,L-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine

5. L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds