An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes-Reference-Cited by-同舟云学术

An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes

Published:2020-11-05 Issue:45 Volume:59 Page:4321-4335
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Sparks Robert P.¹,Arango Andres S.²^ORCID,Jenkins Jermaine L.³,Guida Wayne C.⁴,Tajkhorshid Emad¹²⁵^ORCID,Sparks Charles E.⁶,Sparks Janet D.⁶,Fratti Rutilio A.¹²^ORCID

Affiliation:

1. Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States

2. Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States

3. Structural Biology & Biophysics Facility, University of Rochester Medical Center, Rochester, New York 14642, United States

4. Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States

5. Beckman Institute for Advanced Science & Technology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States

6. Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, United States

Funder

National Center for Research Resources

Division of Molecular and Cellular Biosciences

National Institute of Allergy and Infectious Diseases

Office of Naval Research Global

National Institute of General Medical Sciences

School of Medicine and Dentistry, University of Rochester

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00741

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2. Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting

3. Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles

4. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

5. Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View

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