Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory-Reference-Cited by-同舟云学术

Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory

Published:2021-02-15 Issue:8 Volume:60 Page:607-620
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Vavřina Zdeněk¹²^ORCID,Gutten Ondrej¹^ORCID,Smola Miroslav¹,Zavřel Martin¹,Aliakbar Tehrani Zahra¹³^ORCID,Charvát Vilém¹,Kožíšek Milan¹^ORCID,Boura Evzen¹^ORCID,Birkuš Gabriel¹^ORCID,Rulíšek Lubomír¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, Prague 16610, Czech Republic

2. Department of Biochemistry, Faculty of Science, Charles University, Prague 110 00, Czech Republic

3. Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Průmyslová 595, Vestec 252 50, Czech Republic

Funder

European Regional Development Fund

Grantov? Agentura Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00949

Reference69 articles.

1. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2. STING and the innate immune response to nucleic acids in the cytosol

3. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

4. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

5. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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