Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes

Author:

Hayakawa Shun1,Matsushita Takahiko2,Yokoi Yasuhiro1,Wakui Hajime1,Garcia-Martin Fayna1ORCID,Hinou Hiroshi1ORCID,Matsuoka Koji2ORCID,Nouso Kazuhiro3,Kamiyama Toshiya4,Taketomi Akinobu4,Nishimura Shin-Ichiro1ORCID

Affiliation:

1. Graduate School of Life Science and Faculty of Advanced Life Science, Hokkaido University, N22, W11, Kita-ku, Sapporo 001-0021, Japan

2. Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan

3. Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan

4. Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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