Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography-Reference-Cited by-同舟云学术

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography

Published:2020-01-30 Issue:8 Volume:59 Page:955-963
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Batra Vinod K.¹,Alnajjar Khadijeh S.²^ORCID,Sweasy Joann B.²,McKenna Charles E.³^ORCID,Goodman Myron F.⁴^ORCID,Wilson Samuel H.¹^ORCID

Affiliation:

1. Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, United States

2. Department of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, United States

3. Department of Chemistry, University of Southern California, Los Angeles, California 90089-1062, United States

4. Department of Biological Sciences, University of Southern California, Los Angeles, California 90089-0371, United States

Funder

National Institute of Environmental Health Sciences

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b01072