Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity-Reference-Cited by-同舟云学术

Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity

Published:2019-12-23 Issue:4 Volume:59 Page:479-490
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Chambers Jennifer M.¹,Miller Wade²,Quichocho Giovanni³,Upadhye Viraj³,Matteo Diego Avellaneda³,Bobkov Andrey A.⁴,Sohl Christal D.³^ORCID,Schiffer Jamie M.⁵^ORCID

Affiliation:

1. Schrödinger, 120 West 45th Street, New York, New York 10036, United States

2. Schrödinger, 222 Third Street, Suite 2230, Cambridge, Massachusetts 02142, United States

3. Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182, United States

4. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States

5. Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States

Funder

National Cancer Institute

American Cancer Society

National Institute of General Medical Sciences

California Metabolic Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b01023

Reference43 articles.

1. An Integrated Genomic Analysis of Human Glioblastoma Multiforme

2. IDH1andIDH2Mutations in Gliomas

3. Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

4. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

5. Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

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