Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles

Author:

Shafieichaharberoud Fatemeh12,Lang Shuyao12,Whalen Connor3,Rivera Quiles Cristina4ORCID,Purcell Lillie1,Talbot Cameron12,Wang Pengfei5ORCID,Norton Elizabeth B.6,Mazei-Robison Michelle4,Sulima Agnieszka7,Jacobson Arthur E.7,Rice Kenner C.7,Matyas Gary R.3ORCID,Huang Xuefei128ORCID

Affiliation:

1. Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, Michigan 48824, United States

2. Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States

3. Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States

4. Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, United States

5. Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States

6. Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States

7. Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, United States

8. Department of Biomedical Engineering, Michigan State University, East Lansing, Michigan 48824, United States

Funder

Henry M. Jackson Foundation

Medical Research and Materiel Command

National Institute of Allergy and Infectious Diseases

Michigan State University

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Reference66 articles.

1. Drug overdose deaths in the U.S. top 100,000 annually. https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2021/20211117.htm#:~:text=Provisional%20data%20from%20CDC%27s%20National,same%20period%20the%20year%20before (accessed Oct 22, 2023).

2. Key substance use and mental health indicators in the United States: results from the 2019 National Survey on Drug Use and Health. 2020. https://www.opioidlibrary.org/document/key-substance-use-and-mental-health-indicators-in-the-united-states-results-from-the-2019-national-survey-on-drug-use-and-health/ (accessed Oct 22, 2023).

3. Tanz, L. J.; Dinwiddie, A. T.; Snodgrass, S.; O’Donnell, J.; Mattson, C. L.; Davis, N. L. Drug overdose deaths in 28 states and the District of Columbia: 2020 data from the State Unintentional Drug Overdose Reporting System. 2022. https://www.cdc.gov/drugoverdose/databriefs/pdf/sudors_data-brief_number_1.pdf (accessed Oct 22, 2023).

4. Changes in characteristics of drug overdose death trends during the COVID-19 pandemic

5. Drug Overdose Deaths Before and After Shelter-in-Place Orders During the COVID-19 Pandemic in San Francisco

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