A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity-Reference-Cited by-同舟云学术

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity

Published:2022-09-15 Issue:10 Volume:33 Page:1860-1866
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Rady Tony¹,Turelli Lorenzo¹,Nothisen Marc¹,Tobaldi Elisabetta¹,Erb Stéphane²³,Thoreau Fabien¹,Hernandez-Alba Oscar²³,Cianferani Sarah²³^ORCID,Daubeuf François⁴,Wagner Alain¹^ORCID,Chaubet Guilhem¹^ORCID

Affiliation:

1. Bio-Functional Chemistry (UMR 7199), LabEx Medalis, University of Strasbourg, 74 Route du Rhin, 67400Illkirch-Graffenstaden, France

2. Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC, UMR 7178, Université de Strasbourg, CNRS, 67087Strasbourg, France

3. Infrastructure Nationale de Protéomique ProFI − FR2048, 67087Strasbourg, France

4. PCBIS − TechMedILL (CNRS - UMS 3286), ESBS - Pôle API, 300 boulevard Sébastien Brant, CS 10413, 67412Illkirch-Graffenstaden Cedex, France

Funder

Agence Nationale de la Recherche

Universit? de Strasbourg

Sanofi

Centre International de Recherche aux Fronti?res de la Chimie

H2020 Marie Sklodowska-Curie Actions

Centre National de la Recherche Scientifique

R?gion Grand-Est

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.2c00314

Reference28 articles.

1. Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry

2. Cleavable linkers in chemical biology

3. A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate

4. Development of a Novel Chemical Probe for the Selective Enrichment of Phosphorylated Serine- and Threonine-Containing Peptides

5. Tunable Bifunctional Silyl Ether Cross-Linkers for the Design of Acid-Sensitive Biomaterials

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