Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody

Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody–Drug Conjugates

Published:2024-01-24 Issue:2 Volume:35 Page:140-146
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Zhang Alan¹,Seiss Katherine²,Laborde Laurent³,Palacio-Ramirez Sebastian⁴,Guthy Daniel³^ORCID,Lanter Mylene³,Lorber Julien⁵,Vulpetti Anna⁵^ORCID,Arista Luca⁵,Zoller Thomas⁵,Radimerski Thomas³,Thoma Claudio³,Hebach Christina³,Tschantz William R.⁴,Karpov Alexei⁵^ORCID,Hollingworth Gregory J.⁵,D’Alessio Joseph A.²,Ferretti Stephane³,Burger Matthew T.¹^ORCID

Affiliation:

1. Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139 United States

2. Oncology Biotherapeutics, Novartis Biomedical Research, Cambridge, Massachusetts 02139 United States

3. Oncology, Novartis Biomedical Research, CH-4002 Basel, Switzerland

4. Novartis Biologics Center, Novartis Biomedical Research, Cambridge, Massachusetts 02139 United States

5. Global Discovery Chemistry, Novartis Biomedical Research, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.3c00535

Reference34 articles.

1. Antibody–Drug Conjugates: The Last Decade

2. Antibody–drug conjugates come of age in oncology

3. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

4. Phthalimide conjugation as a strategy for in vivo target protein degradation

5. Induced protein degradation: an emerging drug discovery paradigm

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