Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor

Author:

Naganuma Miyako12,Ohoka Nobumichi3ORCID,Tsuji Genichiro1ORCID,Inoue Takao3,Naito Mikihiko4ORCID,Demizu Yosuke12ORCID

Affiliation:

1. Division of Organic Chemistry, National Institute of Health Sciences, Kanagawa 210-9501, Japan

2. Graduate School of Medical Life Science, Yokohama City University, Kanagawa 236-0027, Japan

3. Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kanagawa 210-9501, Japan

4. Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 110-0033, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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