Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition-Reference-Cited by-同舟云学术

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition

Published:2019-12-02 Issue:1 Volume:31 Page:64-73
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Tran Hue N. T.¹,Tran Poanna¹,Deuis Jennifer R.¹,Agwa Akello J.¹^ORCID,Zhang Alan H.²,Vetter Irina¹³,Schroeder Christina I.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

2. Center for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia

3. School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.9b00744

Reference58 articles.

1. The NaV1.7 sodium channel: from molecule to man

2. NaV1.7 as a pain target – From gene to pharmacology

3. NaV1.9: a sodium channel linked to human pain

4. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

5. Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

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