Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs-Reference-Cited by-同舟云学术

Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs

Published:2018-01-31 Issue:2 Volume:29 Page:486-492
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Forte Nafsika¹,Livanos Maria²,Miranda Enrique²,Morais Maurício¹,Yang Xiaoping¹,Rajkumar Vineeth S.²,Chester Kerry A.²^ORCID,Chudasama Vijay¹³,Baker James R.¹^ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, United Kingdom

2. Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, United Kingdom

3. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-004 Lisbon, Portugal

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.7b00795

Reference50 articles.

1. Dual targeting strategies with bispecific antibodies

2. Bispecific antibody conjugates in therapeutics

3. Synthetic fusion protein design and applications

4. Transforming the treatment for hemophilia B patients: update on the clinical development of recombinant fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP)

5. Bispecific T-Cell Engaging Antibodies for Cancer Therapy: Figure 1.

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