Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe-Reference-Cited by-同舟云学术

Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe

Published:2020-08-25 Issue:9 Volume:31 Page:2241-2251
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Asano Toshifumi¹^ORCID,Nagayo Yuri²,Tsuda Satoru¹,Ito Azusa¹,Kobayashi Wataru³,Fujita Kosuke³,Sato Kota¹⁴,Nishiguchi Koji M.⁵,Kunikata Hiroshi¹³,Fujioka Hiroyoshi⁶,Kamiya Mako²^ORCID,Urano Yasuteru²^ORCID,Nakazawa Toru¹³⁴⁵⁷

Affiliation:

1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan

2. Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan

3. Department of Retinal Disease Control, Ophthalmology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan

4. Collaborative Program of Ophthalmic Drug Discovery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan

5. Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan

6. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-8654, Japan

7. Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan

Funder

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00435

Reference31 articles.

1. Critical role of calpain in axonal damage-induced retinal ganglion cell death

2. Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor

3. Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells

4. The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation

5. Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease

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