BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation

Author:

Silva Maria J. S. A.12,Zhang Yiyi2,Vinck Robin2,Santos Fábio M. F.1,António João P. M.1,Gourdon-Grünewaldt Lisa23,Zaouter Charlotte3,Castonguay Annie3,Patten Shunmoogum A.3,Cariou Kevin2,Boscá Francisco4,Nájera Francisco5ORCID,Arteaga Jesús F.6ORCID,Gasser Gilles2ORCID,Pischel Uwe6ORCID,Gois Pedro M. P.1ORCID

Affiliation:

1. Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa 1649-003, Portugal

2. Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris F-75005, France

3. INRS - Institut Armand-Frappier, Université du Québec, 531 boul. des Prairies, Laval , QuebecH7V 1B7, Canada

4. Instituto de Tecnología Química, Universitat Politècnica de València − Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, Valencia 46022, Spain

5. Departamento de Química Orgánica, and Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina − IBIMA, Universidad de Málaga, Campus Teatinos s/n, 29071, Plataforma Bionand, Parque Tecnológico de Andalucía, Málaga 29590, Spain

6. CIQSO-Centre for Research in Sustainable Chemistry and Department of Chemistry, University of Huelva, Campus de El Carmen s/n, Huelva 21071, Spain

Funder

Universidad de Huelva

Fonds de Recherche du Qu?bec - Sant?

?cole Normale Sup?rieure

Agence Nationale de la Recherche

Ministerio de Ciencia e Innovaci?n

Canada Foundation for Innovation

China Scholarship Council

Natural Sciences and Engineering Research Council of Canada

Funda??o para a Ci?ncia e a Tecnologia

H2020 European Research Council

Ag?ncia Valenciana de la Innovaci?

French Government

Institut Q-LIFE

Fonds de recherche du Qu?bec - Nature et technologies

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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