Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody

Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates

Published:2018-12-13 Issue:1 Volume:30 Page:200-209
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Ratnayake Anokha S.¹,Chang Li-ping¹,Tumey L. Nathan¹,Loganzo Frank²,Chemler Joseph A.¹,Wagenaar Melissa¹,Musto Sylvia²,Li Fengping¹,Janso Jeffrey E.¹,Ballard T. Eric¹,Rago Brian¹,Steele Greg L.¹,Ding WeiDong¹,Feng Xidong¹,Hosselet Christine²,Buklan Vlad²,Lucas Judy²,Koehn Frank E.¹,O’Donnell Christopher J.¹,Graziani Edmund I.¹^ORCID

Affiliation:

1. Medicine Design, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States

2. Oncology Research, Pfizer Worldwide Research and Development, 401 North Middletown Road, Pearl River, New York 10965, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.8b00843

Reference59 articles.

1. Coupling of Cyclic Chemotherapeutic Compounds to Immune Gamma-Globulins

2. Strategies and challenges for the next generation of antibody–drug conjugates