Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition-Reference-Cited by-同舟云学术

Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition

Published:2022-04-21 Issue:5 Volume:33 Page:795-806
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Hayun Hezi¹²,Arkadash Valeria¹²,Sananes Amiram¹²,Arbely Eyal³²^ORCID,Stepensky David⁴,Papo Niv¹²^ORCID

Affiliation:

1. Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel

2. The National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel

3. Department of Chemistry, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel

4. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel

Funder

German-Israeli Foundation for Scientific Research and Development

United States - Israel Binational Science Foundation

Worldwide Cancer Research

European Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.2c00059

Reference72 articles.

1. Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2. Imbalance between MMP-2, 9 and TIMP-1 promote the invasion and metastasis of renal cell carcinoma via SKP2 signaling pathways

3. Progress in matrix metalloproteinase research

4. New functions for the matrix metalloproteinases in cancer progression

5. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin

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