Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly-Reference-Cited by-同舟云学术

Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly

Published:2022-02-07 Issue:2 Volume:33 Page:333-342
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Dinesen Anders¹,Winther Alexander¹,Wall Archie²,Märcher Anders³,Palmfeldt Johan⁴,Chudasama Vijay²^ORCID,Wengel Jesper⁵^ORCID,Gothelf Kurt V.³^ORCID,Baker James R.²^ORCID,Howard Kenneth A.¹^ORCID

Affiliation:

1. Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark

2. Department of Chemistry, University College London, London WC1H 0AJ, U.K.

3. Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark

4. Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus N, Denmark

5. Nucleic Acid Center, Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, DK-5230 Odense M, Denmark

Funder

Novo Nordisk Fonden

Villum Fonden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.1c00561

Reference50 articles.

1. Administration, distribution, metabolism and elimination of polymer therapeutics

2. Albumin as a versatile platform for drug half-life extension

3. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

4. Longer action means better drug: Tuning up protein therapeutics

5. Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin

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