Combinatorial Synthesis of a Lipidoid Library by Thiolactone Chemistry: In Vitro Screening and In Vivo Validation for siRNA Delivery-Reference-Cited by-同舟云学术

Combinatorial Synthesis of a Lipidoid Library by Thiolactone Chemistry: In Vitro Screening and In Vivo Validation for siRNA Delivery

Published:2020-02-18 Issue:3 Volume:31 Page:852-860
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Molla Mijanur R.¹²^ORCID,Chakraborty Shraddha¹^ORCID,Munoz−Sagredo Leonel¹³,Drechsler Markus⁴,Orian−Rousseau Véronique¹,Levkin Pavel A.¹^ORCID

Affiliation:

1. Institute of Biological and Chemical Systems−Functional Molecular Systems (IBCS−FMS), Karlsruhe Institute of Technology (KIT), Hermann−von−Helmholtz-Platz 1, 76344 Eggenstein−Leopoldshafen, Germany

2. Department of Chemistry, University of Calcutta (Rashbehari Siksha Prangan), 92 A. P. C. Road, Kolkata 700009, India

3. Faculty of Medicine, University of Valparaiso, Hontaneda 2653, 2341369 Valparaiso, Chile

4. Bavarian Polymer Institute (BPI), University of Bayreuth, Universitaetsstr. 30, D−95440 Bayreuth, Germany

Funder

Alexander von Humboldt-Stiftung

FP7 Ideas: European Research Council

Helmholtz Association

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00013

Reference40 articles.

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2. RNAi-based nanomedicines for targeted personalized therapy

3. Alnylam RNAi Roundtable : Conjugate Delivery. Available at: https://www.alnylam.com/web/assets/ALNY-RNAiRoundtable-ConjugateDelivery-Dec-14-2012.pdf.

4. Nanovector delivery of siRNA for cancer therapy

5. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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