Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging-Reference-Cited by-同舟云学术

Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging

Published:2023-11-10 Issue:12 Volume:34 Page:2187-2193
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Murakami Eitaro¹,Nakamori Masayuki²,Nakatani Kazuhiko¹^ORCID,Shibata Tomonori¹^ORCID,Tainaka Kazuki³

Affiliation:

1. Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research), Osaka University, Osaka 567-0047, Japan

2. Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan

3. Department of System Pathology for Neurological Disorders, Center for Bioresources, Brain Research Institute, Niigata University, Niigata 951-8585, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.3c00470

Reference39 articles.

1. Molecular mechanisms underlying nucleotide repeat expansion disorders

2. Polyglutamine neurodegeneration: protein misfolding revisited

3. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

4. Huntington Disease

5. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

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