Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification-Reference-Cited by-同舟云学术

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

Published:2018-02-26 Issue:4 Volume:29 Page:1155-1167
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Su Dian¹^ORCID,Kozak Katherine R.¹,Sadowsky Jack¹,Yu Shang-Fan¹,Fourie-O’Donohue Aimee¹,Nelson Christopher¹,Vandlen Richard¹^ORCID,Ohri Rachana¹,Liu Luna¹,Ng Carl¹,He Jintang¹^ORCID,Davis Helen¹,Lau Jeff¹,Del Rosario Geoffrey¹,Cosino Ely¹,Cruz-Chuh Josefa dela¹,Ma Yong¹^ORCID,Zhang Donglu¹,Darwish Martine¹,Cai Wenwen²,Chen Chunjiao²,Zhou Hongxiang²,Lu Jiawei²,Liu Yichin¹,Kaur Surinder¹,Xu Keyang¹,Pillow Thomas H.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Wuxi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.7b00785

Reference55 articles.

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2. Shen, W.C. (2015) Antibody-Drug Conjugates: A Historical Review. Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (Wang, J., Shen, W.C., and Zaro, J. L., Eds.) pp 3–7, Chapter 1, Springer, New York.

3. Antibody–drug conjugates as novel anti-cancer chemotherapeutics

4. Antibody Drug Conjugates for Cancer Therapy

5. Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

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