Welding PROxAb Shuttles: A Modular Approach for Generating Bispecific Antibodies via Site-Specific Protein–Protein Conjugation-Reference-Cited by-同舟云学术

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Welding PROxAb Shuttles: A Modular Approach for Generating Bispecific Antibodies via Site-Specific Protein–Protein Conjugation

Published:2024-05-29 Issue:6 Volume:35 Page:780-789
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Lehmann Tanja¹²,Schneider Hendrik²,Tonillo Jason²,Schanz Jennifer²,Schwarz Daniel³,Schröter Christian²,Jäger Sebastian²^ORCID,Kolmar Harald¹,Hecht Stefan²,Anderl Jan²,Rasche Nicolas²,Rieker Marcel²,Dickgiesser Stephan²^ORCID

Affiliation:

1. Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, 64287 Darmstadt, Germany

2. ADCs & Targeted NBE Therapeutics, Merck KGaA, 64293 Darmstadt , Germany

3. Discovery Pharmacology, Merck KGaA, 64293 Darmstadt, Germany

Funder

Merck KGaA, Darmstadt, Germany

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.4c00124

Reference51 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. Catalytic in vivo protein knockdown by small-molecule PROTACs

3. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

4. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

5. Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

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