A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide-Reference-Cited by-同舟云学术

A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide

Published:2019-08-05 Issue:9 Volume:30 Page:2340-2348
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

St. Amant Andre H.¹^ORCID,Huang Fengying²,Lin Jia²,Lemen Daniel²^ORCID,Chakiath Chacko²,Mao Shenlan³,Fazenbaker Christine³,Zhong Haihong³,Harper Jay³,Xu Wenshu⁴,Patel Neki⁴,Adams Lauren⁴,Vijayakrishnan Balakumar⁴,Howard Philip W.⁴,Marelli Marcello³,Wu Herren²,Gao Changshou²,Read de Alaniz Javier¹^ORCID,Christie R. James²^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, United States

2. Antibody Discovery and Protein Engineering Department, AstraZeneca R&D, Gaithersburg, Maryland 20878, United States

3. AstraZeneca Oncology R&D, Gaithersburg, Maryland 20878, United States

4. Spirogen, London E1 2AX, United Kingdom

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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