Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia

Author:

Lee Dian-Jang12ORCID,Kessel Eva12,Lehto Taavi1,Liu Xueying3,Yoshinaga Naoto4,Padari Kärt5,Chen Ying-Chen6,Kempter Susanne7,Uchida Satoshi34,Rädler Joachim O.27,Pooga Margus5,Sheu Ming-Thau6,Kataoka Kazunori38ORCID,Wagner Ernst12ORCID

Affiliation:

1. Department of Pharmacy and Center for NanoScience, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany

2. Nanosystems Initiative Munich (NIM), Schellingstr. 4, 80799 Munich, Germany

3. Innovation Center of NanoMedicine (iCONM), Institute of Industry Promotion-Kawasaki, 3-25-14 Tonomachi, Kawasaki-ku, 210-0821 Kawasaki, Japan

4. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656 Tokyo, Japan

5. Institute of Molecular and Cell Biology and Institute of Technology, University of Tartu, 23 Riia Str., 51010 Tartu, Estonia

6. School of Pharmacy, College of Pharmacy, Taipei Medical University, No. 250, Wuxin St., 11031 Taipei, Taiwan

7. Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität München, Geschwister-Scholl-Platz 1, 80539 Munich, Germany

8. Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan

Funder

Bayerische Forschungsstiftung

Deutsche Forschungsgemeinschaft

Japan Science and Technology Agency

National Natural Science Foundation of China

European Molecular Biology Organization

Eesti Teadusagentuur

Haridus- ja Teadusministeerium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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