Diverging DOS Strategy Using an Allene-Containing Tryptophan Scaffold and a Library Design that Maximizes Biologically Relevant Chemical Space While Minimizing the Number of Compounds-Reference-Cited by-同舟云学术

Diverging DOS Strategy Using an Allene-Containing Tryptophan Scaffold and a Library Design that Maximizes Biologically Relevant Chemical Space While Minimizing the Number of Compounds

Published:2011-02-18 Issue:2 Volume:13 Page:166-174
ISSN:2156-8952
Container-title:ACS Combinatorial Science
language:en
Short-container-title:ACS Comb. Sci.

Author:

Painter Thomas O.¹,Wang Lirong²,Majumder Supriyo¹,Xie Xiang-Qun²,Brummond Kay M.¹

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

2. Department of Pharmaceutical Sciences, School of Pharmacy, Drug Discovery Institute, Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/co100052s

Reference32 articles.

1. Diversity-oriented synthesis: exploring the intersections between chemistry and biology

2. Current strategies for diversity-oriented synthesis

3. Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry

4. Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity

5. Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds

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