Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues
Author:
Affiliation:
1. Division of Pharmaceutical Sciences, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States
2. Thallion Pharmaceuticals, Inc., Montreal, Quebec H4S 2C8, Canada
Funder
National Institutes of Health
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi501396v
Reference53 articles.
1. Iso-Migrastatin Congeners from Streptomyces platensis and Generation of a Glutarimide Polyketide Library Featuring the Dorrigocin, Lactimidomycin, Migrastatin, and NK30424 Scaffolds
2. Multifaceted Modes of Action for the Glutarimide-Containing Polyketides Revealed
3. Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.
4. Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities.
5. Absolute Configuration of Migrastatin, a Novel 14-Membered Ring Macrolide.
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