1. Process Engineering Group, Instituto de Investigaciones Marinas (CSIC), C/Eduardo Cabello 6, 36208 Vigo, Spain, Chemical Production Engineering, Janssen Pharmaceutica, Janssen Pharmaceuticalaan 3 (Building 210), B-2440 Geel, Belgium, and BioTeC (Bioprocess Technology and Control), Chemical Engineering Department, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B-3001 Heverlee, Belgium