A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability-Reference-Cited by-同舟云学术

A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability

Published:2008-07-17 Issue:15 Volume:51 Page:4465-4475
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rawson Thomas E.¹,Rüth Matthias¹,Blackwood Elizabeth¹,Burdick Dan¹,Corson Laura¹,Dotson Jenna¹,Drummond Jason¹,Fields Carter¹,Georges Guy J.¹,Goller Bernhard¹,Halladay Jason¹,Hunsaker Thomas¹,Kleinheinz Tracy¹,Krell Hans-Willi¹,Li Jun¹,Liang Jun¹,Limberg Anja¹,McNutt Angela¹,Moffat John¹,Phillips Gail¹,Ran Yingqing¹,Safina Brian¹,Ultsch Mark¹,Walker Leslie¹,Wiesmann Christian¹,Zhang Birong¹,Zhou Aihe¹,Zhu Bing-Yan¹,Rüger Petra¹,Cochran Andrea G.¹

Affiliation:

1. Departments of Small Molecule Drug Discovery, Cell Cycle and Global Regulators, Translational Oncology, and Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, and Departments of Medicinal Chemistry, Cell Biology, and HTS and Biochemistry, Pharma Research, Roche Diagnostics GmbH, D-82372 Penzberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800052b

Reference48 articles.

1. Aurora-kinase inhibitors as anticancer agents

2. Aurora kinases: shining lights on the therapeutic horizon?

3. Targeted anti-mitotic therapies: can we improve on tubulin agents?

4. Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

5. The cellular geography of Aurora kinases

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