Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine-Reference-Cited by-同舟云学术

Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Published:1999-03-12 Issue:7 Volume:42 Page:1115-1122
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Esch Iwan J. P.¹,Vollinga Roeland C.¹,Goubitz Kees¹,Schenk Henk¹,Appelberg Ulf¹,Hacksell Uli¹,Lemstra Sylvia¹,Zuiderveld Obbe P.¹,Hoffmann Marcel¹,Leurs Rob¹,Menge Wiro M. P. B.¹,Timmerman Henk¹

Affiliation:

1. Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands, Laboratory for Crystallography, Institute for Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, and Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Box 574, Uppsala University, S-751 23 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9810912

Reference36 articles.

1. Molecular pharmacological aspects of histamine receptors

2. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

3. Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex

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