1. Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, LQBB-Department of Pharmacy, The Federal University of Parana, Curitiba 80310-170, Brazil, and Cancer Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co., Ltd., Saitama, 357-8527, Japan