Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia-Reference-Cited by-同舟云学术

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Published:2010-05-21 Issue:12 Volume:53 Page:4603-4614
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pinard Emmanuel¹,Alanine Alexander¹,Alberati Daniela¹,Bender Markus¹,Borroni Edilio¹,Bourdeaux Patrick¹,Brom Virginie¹,Burner Serge¹,Fischer Holger¹,Hainzl Dominik¹,Halm Remy¹,Hauser Nicole¹,Jolidon Synese¹,Lengyel Judith¹,Marty Hans-Peter¹,Meyer Thierry¹,Moreau Jean-Luc¹,Mory Roland¹,Narquizian Robert¹,Nettekoven Mathias¹,Norcross Roger D.¹,Puellmann Bernd¹,Schmid Philipp¹,Schmitt Sebastien¹,Stalder Henri¹,Wermuth Roger¹,Wettstein Joseph G.¹,Zimmerli Daniel¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., Pharmaceutical Division, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100210p

Reference47 articles.

1. Schizophrenia: Moving Beyond Monoamine Antagonists

2. Glutamate and Schizophrenia: Phencyclidine, N‐Methyl‐d‐Aspartate Receptors, and Dopamine–Glutamate Interactions

3. Glycine Transporter 1 Inhibitors and Modulation of NMDA Receptor-Mediated Excitatory Neurotransmission

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