Discovery of Tofogliflozin, a Novel C-Arylglucoside with an O-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

Discovery of Tofogliflozin, a Novel C-Arylglucoside with an O-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Published:2012-08-28 Issue:17 Volume:55 Page:7828-7840
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ohtake Yoshihito¹,Sato Tsutomu¹,Kobayashi Takamitsu¹,Nishimoto Masahiro¹,Taka Naoki¹,Takano Koji¹,Yamamoto Keisuke¹,Ohmori Masayuki¹,Yamaguchi Marina¹,Takami Kyoko¹,Yeu Sang-Yong²,Ahn Koo-Hyeon³,Matsuoka Hiroharu¹,Morikawa Kazumi¹,Suzuki Masayuki¹,Hagita Hitoshi²,Ozawa Kazuharu¹,Yamaguchi Koji¹,Kato Motohiro¹,Ikeda Sachiya¹

Affiliation:

1. Research Division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan

2. Chugai Research Institute for Medical Science, Inc., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan

3. C&C Research Laboratories, DRC Natural Sciences Campus, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300884k

Reference68 articles.

1. Diabetes: Fact Sheet No. 312World Health Organization:Geneva, 2011; http://www.who.int/mediacentre/factsheets/fs312/en/.

2. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

3. Microvascular and Macrovascular Complications of Diabetes

4. SGLT2 inhibition — a novel strategy for diabetes treatment

5. Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for New Anti-Diabetic Agent

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