1. Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled
2. Jencks, W. P.Catalysis in Chemistry and Enzymology; Dover: New York, 1987; pp 107−111. Abeles, R. H.; Frey, P. A.; Jencks, W. P.Biochemistry; Jones and Bartlett: Boston, 1992; pp 295−328.
3. The rate constant for hydrolysis of ImP-is 2 × 10-5M-1min-1at 40.1 °C (ref 8), 103-fold faster than the rate constant of 2 × 10-8M-1min-1for hydrolysis of PNPP2-at 39 °C (ref 4). An equilibrium constant of 4 × 105M has been calculated for the hydrolysis of ImP-, 104-fold larger than the equilibrium constant of 55 M for hydrolysis of HOPO32-(ref 14).