Discovery and Profiling of a Selective and Efficacious Syk Inhibitor-Reference-Cited by-同舟云学术

Discovery and Profiling of a Selective and Efficacious Syk Inhibitor

Published:2015-02-09 Issue:4 Volume:58 Page:1950-1963
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thoma Gebhard,Smith Alexander B.,van Eis Maurice J.,Vangrevelinghe Eric,Blanz Joachim,Aichholz Reiner,Littlewood-Evans Amanda,Lee Christian C.¹,Liu Hong¹,Zerwes Hans-Günter

Affiliation:

1. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5018863

Reference30 articles.

1. The SYK tyrosine kinase: a crucial player in diverse biological functions

2. Autoinhibition and adapter function of Syk

3. The tyrosine kinase network regulating mast cell activation

4. Syk and pTyr'd: Signaling through the B cell antigen receptor

5. SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

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