Energy Blocker Lonidamine Reverses Nimustine Resistance in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis Disruption, and O6-Methylguanine-DNA Methyltransferase Downregulation: In Vitro and In Vivo Validation-Reference-Cited by-同舟云学术

Energy Blocker Lonidamine Reverses Nimustine Resistance in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis Disruption, and O⁶-Methylguanine-DNA Methyltransferase Downregulation: In Vitro and In Vivo Validation

Published:2024-04-17 Issue:5 Volume:7 Page:1518-1532
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Huang Yaxing¹,Wang Peng²,Fan Tengjiao¹³,Zhang Na¹,Zhao Lijiao¹^ORCID,Zhong Rugang¹,Sun Guohui¹^ORCID

Affiliation:

1. Beijing Key Laboratory of Environment & Viral Oncology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China

2. Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

3. Department of Medical Technology, Beijing Pharmaceutical University of Staff and Workers, Beijing 100079, China

Funder

Beijing Municipal Natural Science Foundation

National Natural Science Foundation of China

Beijing Municipal Education Commission

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00085

Reference46 articles.

1. Hallmarks of Cancer: The Next Generation

2. Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment

3. The roles of glucose metabolic reprogramming in chemo- and radio-resistance

4. Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy

5. 3-Bromopyruvate treatment induces alterations of metabolic and stress-related pathways in glioblastoma cells

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1. Lonidamine Increases the Cytotoxic Effect of 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea via Energy Inhibition, Disrupting Redox Homeostasis, and Downregulating MGMT Expression in Human Lung Cancer Cell Line;ACS Omega;2024-08-17