Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu

Author:

Machulkin Aleksei E.12ORCID,Petrov Stanislav A.1,Bodenko Vitalina34,Larkina Mariia S.35ORCID,Plotnikov Evgenii36,Yuldasheva Feruza3,Tretyakova Maria3,Bezverkhniaia Ekaterina37,Zyk Nikolay Yu.1,Stasyuk Elena8,Zelchan Roman3,Majouga Alexander G.9ORCID,Tolmachev Vladimir10,Orlova Anna7ORCID,Beloglazkina Elena K.1ORCID,Yusubov Mekhman S.3

Affiliation:

1. Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russian Federation

2. Department for Biochemistry, People’s Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow 117198, Russia

3. Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia

4. Scientific and Educational Laboratory of Chemical and Pharmaceutical Research, Siberian State Medical University, Tomsk 634050, Russia

5. Department of Pharmaceutical Analysis, Siberian State Medical University, Tomsk 634050, Russia

6. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634014, Russia

7. Department of Medicinal Chemistry, Uppsala University, Uppsala 75183, Sweden

8. School of Nuclear Science and Engineering, Tomsk Polytechnic University, Tomsk 634050, Russia

9. Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russian Federation

10. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75185, Sweden

Funder

Russian Science Foundation

Tomsk Polytechnic University

Publisher

American Chemical Society (ACS)

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