Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy-Reference-Cited by-同舟云学术

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Published:2020-07-31 Issue:6 Volume:3 Page:1063-1068
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Kamble Shyam H.¹²,León Francisco³,King Tamara I.¹²,Berthold Erin C.¹²,Lopera-Londoño Carolina³,Siva Rama Raju Kanumuri¹²,Hampson Aidan J.⁴,Sharma Abhisheak¹²,Avery Bonnie A.¹²,McMahon Lance R.⁵,McCurdy Christopher R.²³

Affiliation:

1. Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610-7011, United States

2. Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, Florida 32610-7011, United States

3. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610-7011, United States

4. Division of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, United States

5. Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610-7011, United States

Funder

National Center for Advancing Translational Sciences

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.0c00075

Reference20 articles.

1. From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction