Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

Author:

Free R. Benjamin1ORCID,Nilson Ashley N.1,Boldizsar Noelia M.1ORCID,Doyle Trevor B.1,Rodriguiz Ramona M.2,Pogorelov Vladimir M.2,Machino Mayako3,Lee Kuo Hao3,Bertz Jeremiah W.4,Xu Jinbin5ORCID,Lim Herman D.6,Dulcey Andrés E.7ORCID,Mach Robert H.8ORCID,Woods James H.4,Lane J Robert9ORCID,Shi Lei3ORCID,Marugan Juan J.7ORCID,Wetsel William C.210,Sibley David R.1ORCID

Affiliation:

1. Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland20892, United States

2. Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, 354 Sands Building, 303 Research Drive, Durham, North Carolina27710, United States

3. Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland21224, United States

4. Department of Pharmacology, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, Michigan48109, United States

5. Division of Radiological Sciences, Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri63110, United States

6. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC3052, Australia

7. Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland20850, United States

8. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania19104, United States

9. Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, NottinghamNG7 2UH, United Kingdom

10. Departments of Neurobiology and Cell Biology, Duke University Medical Center, 354 Sands Building, 303 Research Drive, Durham, North Carolina27710, United States

Funder

National Center for Advancing Translational Sciences

National Institute of Neurological Disorders and Stroke

National Health and Medical Research Council

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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