Innate Immunity Plays a Key Role in Controlling Viral Load in COVID-19: Mechanistic Insights from a Whole-Body Infection Dynamics Model

Author:

Dogra Prashant1,Ruiz-Ramírez Javier1,Sinha Kavya2,Butner Joseph D.1,Peláez Maria J.1,Rawat Manmeet3,Yellepeddi Venkata K.45,Pasqualini Renata67,Arap Wadih68,Sostman H. Dirk91011,Cristini Vittorio19,Wang Zhihui19ORCID

Affiliation:

1. Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas 77030, United States

2. DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas 77030, United States

3. Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, United States

4. Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah 84132, United States

5. Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112, United States

6. Rutgers Cancer Institute of New Jersey, Newark, New Jersey 07101, United States

7. Department of Radiation Oncology, Division of Cancer Biology, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States

8. Department of Medicine, Division of Hematology/Oncology, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States

9. Weill Cornell Medicine, New York, New York 10065, United States

10. Houston Methodist Research Institute, Houston, Texas 77030, United States

11. Houston Methodist Academic Institute, Houston, Texas 77030, United States

Funder

Division of Mathematical Sciences

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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