Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin

Author:

Ong Seow Theng1ORCID,Bajaj Saumya1,Tanner Mark R.2,Chang Shih Chieh1,Krishnarjuna Bankala3,Ng Xuan Rui1,Morales Rodrigo A. V.3,Chen Ming Wei1,Luo Dahai1,Patel Dharmeshkumar4,Yasmin Sabina4,Ng Jeremy Jun Heng1,Zhuang Zhong1,Nguyen Hai M.5,El Sahili Abbas6ORCID,Lescar Julien6,Patil Rahul7,Charman Susan A.7,Robins Edward G.89,Goggi Julian L.8,Tan Peng Wen8,Sadasivam Pragalath8,Ramasamy Boominathan8,Hartimath Siddana V.8,Dhawan Vikas1011,Bednenko Janna12,Colussi Paul12,Wulff Heike5,Pennington Michael W.1011,Kuyucak Serdar4,Norton Raymond S.313ORCID,Beeton Christine2,Chandy K. George1

Affiliation:

1. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921

2. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States

3. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

4. School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia

5. Department of Pharmacology, University of California, Davis, California 95616, United States

6. School of Biological Sciences, Nanyang Institute of Structural Biology, Experimental Medicine building, Singapore 636921

7. Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria 3052, Australia

8. Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A* Star), Singapore 138667

9. Singapore Bioimaging Consortium, NUS Clinical Imaging Research Centre (CIRC), Centre for Life Sciences, Singapore 117599

10. Peptides International, Inc., Louisville, Kentucky 40269, United States

11. AmbioPharm Inc., North Augusta, South Carolina 29842, United States

12. TetraGenetics Inc, Arlington, Massachusetts 02474, United States

13. ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

FP7 People: Marie-Curie Actions

Ministry of Education - Singapore

National Health and Medical Research Council

Nanyang Technological University

Lee Kong Chian School of Medicine, Nanyang Technological University

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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