A Scalable 3D High-Content Imaging Protocol for Measuring a Drug Induced DNA Damage Response Using Immunofluorescent Subnuclear γH2AX Spots in Patient Derived Ovarian Cancer Organoids-Reference-Cited by-同舟云学术

A Scalable 3D High-Content Imaging Protocol for Measuring a Drug Induced DNA Damage Response Using Immunofluorescent Subnuclear γH2AX Spots in Patient Derived Ovarian Cancer Organoids

Published:2022-12-12 Issue:1 Volume:6 Page:12-21
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Keles Hakan¹^ORCID,Schofield Christopher A.¹^ORCID,Rannikmae Helena²,Edwards Erin Elizabeth³,Mohamet Lisa¹

Affiliation:

1. Genome Biology, Genomic Sciences, R&D, GSK, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

2. Complex In Vitro Models, In Vitro In Vivo Translation, R&D, GSK, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

3. Genome Biology, Genomic Sciences, R&D, GSK, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00200

Reference25 articles.

1. High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints

2. Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment

3. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

4. Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

5. DNA damage repair in ovarian cancer: unlocking the heterogeneity

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