Preclinical Development of the Na-K-2Cl Co-transporter-1 (NKCC1) Inhibitor ARN23746 for the Treatment of Neurodevelopmental Disorders-Reference-Cited by-同舟云学术

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Preclinical Development of the Na-K-2Cl Co-transporter-1 (NKCC1) Inhibitor ARN23746 for the Treatment of Neurodevelopmental Disorders

Published:2023-01-04 Issue:1 Volume:6 Page:1-11
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Savardi Annalisa¹^ORCID,Patricelli Malizia Andrea¹,De Vivo Marco¹²^ORCID,Cancedda Laura¹³,Borgogno Marco¹^ORCID

Affiliation:

1. IAMA Therapeutics, via Filippo Turati 2/9, 16128 Genoa, Italy

2. Molecular Modeling & Drug Discovery Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy

3. Brain Development & Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy

Funder

Fondazione Telethon

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00197

Reference24 articles.

1. Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

2. NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders

3. The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome

4. Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions

5. Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders

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